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Search Results for " prima 1 "

3

Compounds

Cat No. Product Name Synonyms Targets
T6954 PRIMA-1 2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1 Apoptosis , Others , Ferroptosis , Autophagy
PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
T4414 Eprenetapopt APR-246,PRIMA-1Met Apoptosis , Others , Ferroptosis , p53 , Autophagy
Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of c...
T41068 P53R3 p53
P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53 R273H. This compound exhibits p53-dependent antiproliferativ...
TargetMol